MAP4K4 and IL-6⁺ Th17 cells play important roles in non-obese type 2 diabetes.

ABSTRACT: Obesity is a causal factor of type 2 diabetes (T2D); however, people without obesity (including lean, normal weight, or overweight) may still develop T2D. Non-obese T2D is prevalent in Asia and also frequently occurs in Europe. Recently, multiple evidences oppose the notion that either obesity or central obesity (visceral fat accumulation) promotes non-obese T2D. Several factors such as inflammation and environmental factors contribute to non-obese T2D. According to the data derived from gene knockout mice and T2D clinical samples in Asia and Europe, the pathogenesis of non-obese T2D has been unveiled recently. MAP4K4 downregulation in T cells results in enhancement of the IL-6⁺ Th17 cell population, leading to insulin resistance and T2D in both human and mice. Moreover, MAP4K4

SUBMITTER: Chuang HC 

PROVIDER: S-EPMC5219747 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature