Role of CYP2E1 polymorphisms in breast cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

CYP2E1 polymorphisms have been reported to influence individual's breast cancer susceptibility as a phase I enzyme, but the results of these previous studies remain controversial. We performed a comprehensive meta-analysis to assess their association.

Methods

A comprehensive search of literature included in various databases (PubMed, Web of Science and Google scholar), published before August 2016, was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) calculated in fixed or random-effects models were used to estimate the strength of the associations between three polymorphisms of CYP2E1 and breast cancer susceptibility. Subgroup analysis, sensitivity analysis and test for publication bias were also performed. A total of 11 separate comparisons invol

SUBMITTER: Lu Y 

PROVIDER: S-EPMC5219772 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature