The extracellular proteome of two Bifidobacterium species reveals different adaptation strategies to low iron conditions.

ABSTRACT:

Background

Bifidobacteria are among the first anaerobic bacteria colonizing the gut. Bifidobacteria require iron for growth and their iron-sequestration mechanisms are important for their fitness and possibly inhibit enteropathogens. Here we used combined genomic and proteomic analyses to characterize adaptations to low iron conditions of B. kashiwanohense PV20-2 and B. pseudolongum PV8-2, 2 strains isolated from the feces of iron-deficient African infants and selected for their high iron-sequestering ability.

Results

Analyses of the genome contents revealed evolutionary adaptation to low iron conditions. A ferric and a ferrous iron operon encoding binding proteins and transporters were found in both strains. Remarkably, the ferric iron operon of B. pseudolongum PV8-2 is not

SUBMITTER: Vazquez-Gutierrez P 

PROVIDER: S-EPMC5219805 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature