Suppression of Eosinophil Integrins Prevents Remodeling of Airway Smooth Muscle in Asthma.

ABSTRACT: Background: Airway smooth muscle (ASM) remodeling is an important component of the structural changes to airways seen in asthma. Eosinophils are the prominent inflammatory cells in asthma, and there is some evidence that they contribute to ASM remodeling via released mediators and direct contact through integrin-ligand interactions. Eosinophils express several types of outer membrane integrin, which are responsible for cell-cell and cell-extracellular matrix interactions. In our previous study we demonstrated that asthmatic eosinophils show increased adhesion to ASM cells and it may be important factor contributing to ASM remodeling in asthma. According to these findings, in the present study we investigated the effects of suppression of eosinophil integrin on eosinophil-induced ASM

SUBMITTER: Januskevicius A 

PROVIDER: S-EPMC5220051 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature