Impact of cause of death adjudication on the results of the European prostate cancer screening trial.

ABSTRACT:

Background

The European Randomised Study of Prostate Cancer Screening has shown a 21% relative reduction in prostate cancer mortality at 13 years. The causes of death can be misattributed, particularly in elderly men with multiple comorbidities, and therefore accurate assessment of the underlying cause of death is crucial for valid results. To address potential unreliability of end-point assessment, and its possible impact on mortality results, we analysed the study outcome adjudication data in six countries.

Methods

Latent class statistical models were formulated to compare the accuracy of individual adjudicators, and to assess whether accuracy differed between the trial arms. We used the model to assess whether correcting for adjudication inaccuracies might modify the stud

SUBMITTER: Walter SD 

PROVIDER: S-EPMC5220145 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature