Caphosol for prevention of oral mucositis in pediatric myeloablative haematopoietic cell transplantation.

ABSTRACT:

Background

The primary objective was to determine whether topically administered Caphosol, rinsed orally four times daily at the initiation of conditioning, reduces the duration of severe oral mucositis (OM) compared with placebo among children and adolescents undergoing haematopoietic cell transplantation (HCT).

Methods

This was a Children's Oncology Group multicentre randomised double-blinded placebo-controlled clinical trial. Patients between the ages of 4 and 21 years who were scheduled to undergo myeloablative HCT for any indication were randomised to Caphosol or placebo saline rinses four times daily from initiation of conditioning through day +20. Subjects were assessed daily for OM using the World Health Organisation (WHO) Oral Toxicity Scale, Mouth Pain Categorical

SUBMITTER: Treister N 

PROVIDER: S-EPMC5220147 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature