Cell-Permeable Peptides Containing Cycloalanine Residues.

ABSTRACT: We present here an efficient alternative to N-methylation for the purpose of morphing protein-binding peptides into more serum-stable and cell-permeable compounds. This involves the incorporation of a cycloalanine (CyAla) into a peptide in a way that avoids difficult coupling steps. We demonstrate the utility of this chemistry in creating a cell-permeable derivative of a high-affinity HIV Rev protein-binding peptide.

SUBMITTER: Wu H 

PROVIDER: S-EPMC5220248 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature