Metabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose metabolism.

ABSTRACT:

Objective

Elevated serum ferritin has been linked to type 2 diabetes (T2D) and adverse health outcomes in subjects with the Metabolic Syndrome (MetS). As the mechanisms underlying the negative impact of excess iron have so far remained elusive, we aimed to identify potential links between iron homeostasis and metabolic pathways.

Methods

In a cross-sectional study, data were obtained from 163 patients, allocated to one of three groups: (1) lean, healthy controls (n = 53), (2) MetS without hyperferritinemia (n = 54) and (3) MetS with hyperferritinemia (n = 56). An additional phlebotomy study included 29 patients with biopsy-proven iron overload before and after iron removal. A detailed clinical and biochemical characterization was obtained and metabolomic profiling was perform

SUBMITTER: Stechemesser L 

PROVIDER: S-EPMC5220278 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature