Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling.

ABSTRACT: The hypothalamic arcuate nucleus (ARC) is a major integration center for energy and glucose homeostasis that responds to leptin. Resistance to leptin in the ARC is an important component of the development of obesity and type 2 diabetes. Recently, we showed that Endospanin1 (Endo1) is a negative regulator of the leptin receptor (OBR) that interacts with OBR and retains the receptor inside the cell, leading to a decreased activation of the anorectic STAT3 pathway. Endo1 is up-regulated in the ARC of high fat diet (HFD)-fed mice, and its silencing in the ARC of lean and obese mice prevents and reverses the development of obesity.

Objective

Herein we investigated whether decreased Endo1 expression in the hypothalamic ARC, associated with reduced obesity, could also ameliorate glucose h

SUBMITTER: Vauthier V 

PROVIDER: S-EPMC5220283 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature