Polydatin protects the respiratory system from PM_2.5 exposure.

ABSTRACT: Atmospheric particle is one of the risk factors for respiratory disease; however, their injury mechanisms are poorly understood, and prevention methods are highly desirable. We constructed artificial PM_2.5 (aPM_2.5) particles according to the size and composition of actual PM_2.5 collected in Beijing. Using these artificial particles, we created an inhalation-injury animal model. These aPM_2.5 particles simulate the physical and chemical characteristics of the actual PM_2.5, and inhalation of the aPM_2.5 in rat results in a time-dependent change in lung suggesting a declined lung function, injury from oxidative stress and inflammation in lung. Thus, this aPM_2.5-caused injury animal model may mimic that of the pulmonary

SUBMITTER: Yan XD 

PROVIDER: S-EPMC5220290 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature