Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery.

ABSTRACT: Recombinant adeno-associated virus (rAAV) is an attractive tool for basic science and translational medicine including gene therapy, due to the versatility in its cell and organ transduction. Previous work indicates that rAAV transduction patterns are highly dependent on route of administration. Based on this relationship, we hypothesized that intraperitoneal (IP) administration of rAAV produces unique patterns of tissue tropism. To test this hypothesis, we investigated the transduction efficiency of 12 rAAV serotypes carrying an enhanced green fluorescent protein (EGFP) reporter gene in a panel of 12 organs after IP injection. Our data suggest that IP administration emphasizes transduction patterns that are different from previously reported intravascular delivery methods. Using this appr

SUBMITTER: Ai J 

PROVIDER: S-EPMC5220346 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature