Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1.

ABSTRACT:

Objective

Celastrol was recently identified as a potential novel treatment for obesity. However, the effect of Celastrol on nonalcoholic fatty liver disease (NAFLD) remains elusive. The aim of this study is to evaluate the role of Celastrol in NAFLD.

Methods

Functional studies were performed using wild-type C57BL/6J (WT) mice and liver specific Sirt1-deficient (LKO) mice. The molecular mechanism was explored in primary mouse liver and primary hepatocytes.

Results

When WT mice receiving a high-fat diet (HFD) were treated with Celastrol, reductions in body weight, subcutaneous and visceral fat content, and liver lipid droplet formation were observed, along with reduced hepatic intracellular triglyceride and serum triglyceride, free fatty acid, and ALT concentrati

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5220393 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature