A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism.

ABSTRACT:

Objective

Increased fructose consumption is a contributor to the burgeoning epidemic of non-alcoholic fatty liver disease (NAFLD). Recent evidence indicates that the metabolic hormone FGF21 is regulated by fructose consumption in humans and rodents and may play a functional role in this nutritional context. Here, we sought to define the mechanism by which fructose ingestion regulates FGF21 and determine whether FGF21 contributes to an adaptive metabolic response to fructose consumption.

Methods

We tested the role of the transcription factor carbohydrate responsive-element binding protein (ChREBP) in fructose-mediated regulation of FGF21 using ChREBP knockout mice. Using FGF21 knockout mice, we investigated whether FGF21 has a metabolic function in the context of fructose con

SUBMITTER: Fisher FM 

PROVIDER: S-EPMC5220398 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature