Fetal development of subcutaneous white adipose tissue is dependent on Zfp423.

ABSTRACT:

Objective

Zfp423 is a multi zinc-finger transcription factor expressed in preadipocytes and mature adipocytes in vivo. Our recent work has revealed a critical role for Zfp423 in maintaining the fate of white adipocytes in adult mice through suppression of the beige cell thermogenic gene program; loss of Zfp423 in mature adipocytes of adult mice results in a white-to-beige phenotypic switch. However, the exact requirements of Zfp423 in the fetal stages of early adipose development in vivo have not been clarified.

Method

Here, we utilize two models that confer adipose-specific Zfp423 inactivation during fetal adipose development (Adiponectin-Cre; Zfp423^loxP/loxP and Adiponectin-rtTA; TRE-Cre; Z

SUBMITTER: Shao M 

PROVIDER: S-EPMC5220400 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature