A comparative analysis of transcribed genes in the mouse hypothalamus and neocortex reveals chromosomal clustering.

ABSTRACT: The hypothalamus and neocortex are subdivisions of the mammalian forebrain, and yet, they have vastly different evolutionary histories, cytoarchitecture, and biological functions. In an attempt to define these attributes in terms of their genetic activity, we have compared their genetic repertoires by using the Serial Analysis of Gene Expression database. From a comparison of 78,784 hypothalamus tags with 125,296 neocortical tags, we demonstrate that each structure possesses a different transcriptional profile in terms of gene ontological characteristics and expression levels. Despite its more recent evolutionary history, the neocortex has a more complex pattern of gene activity. Gene identities and levels of gene expression were mapped to their chromosomal positions by using in silico def

SUBMITTER: Boon WM 

PROVIDER: S-EPMC522044 | biostudies-literature | 2004 Oct

REPOSITORIES: biostudies-literature