Within- and Between-Session Changes in Neural Activity During Emotion Processing in Unipolar and Bipolar Depression.

ABSTRACT:

Background

Bipolar disorder (BD) and unipolar depression (UD) can be difficult to distinguish clinically, particularly during episodes of depression. In this study we test for differences between BD, UD, and healthy control (HC) adults regarding within- and between-session changes in BOLD response during implicit emotional processing.

Methods

During fMRI, HC adults (N=19) and depressed adults with UD (N=19) and BD (N=16) performed an implicit emotion-processing task. Each participant was scanned twice, separated by 6-months, resulting in 108 scans. BOLD response and linear change in BOLD response were examined within and between sessions.

Results

We observed within-session linear decreases in BOLD signal (irrespective of group, condition, or session) in the left amygd

SUBMITTER: Fournier JC 

PROVIDER: S-EPMC5220672 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature