Comparative interactomics for virus-human protein-protein interactions: DNA viruses versus RNA viruses.

ABSTRACT: Viruses are obligatory intracellular pathogens and completely depend on their hosts for survival and reproduction. The strategies adopted by viruses to exploit host cell processes and to evade host immune systems during infections may differ largely with the type of the viral genetic material. An improved understanding of these viral infection mechanisms is only possible through a better understanding of the pathogen-host interactions (PHIs) that enable viruses to enter into the host cells and manipulate the cellular mechanisms to their own advantage. Experimentally-verified protein-protein interaction (PPI) data of pathogen-host systems only became available at large scale within the last decade. In this study, we comparatively analyzed the current PHI networks belonging to DNA and RNA vi

SUBMITTER: Durmus S 

PROVIDER: S-EPMC5221455 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature