Maternal stress modifies the effect of exposure to lead during pregnancy and 24-month old children's neurodevelopment.

ABSTRACT:

Background

Lead and psychosocial stress disrupt similar but not completely overlapping mechanisms. Exposure during the prenatal period to each of these insults singularly has been found to alter normal neurodevelopment; however, longitudinal associations with stress modifying the effect of lead have not been sufficiently analyzed in epidemiologic studies.

Objective

To evaluate prenatal stress as an effect modifier of gestational lead neurotoxicity.

Methods

We used a structural equations modeling approach with a trivariate response to evaluate cognitive, language and motor scores of the Bayley Scales of Infant Development-III in 24month-old children (n=360). Maternal blood lead levels were measured at the 2nd and 3rd trimester and psychosocial stress during pregnancy w

SUBMITTER: Tamayo Y Ortiz M 

PROVIDER: S-EPMC5221478 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature