Protein evolution along phylogenetic histories under structurally constrained substitution models.

ABSTRACT:

Motivation

Models of molecular evolution aim at describing the evolutionary processes at the molecular level. However, current models rarely incorporate information from protein structure. Conversely, structure-based models of protein evolution have not been commonly applied to simulate sequence evolution in a phylogenetic framework, and they often ignore relevant evolutionary processes such as recombination. A simulation evolutionary framework that integrates substitution models that account for protein structure stability should be able to generate more realistic in silico evolved proteins for a variety of purposes.

Results

We developed a method to simulate protein evolution that combines models of protein folding stability, such that the fitness depends on the stability o

SUBMITTER: Arenas M 

PROVIDER: S-EPMC5221705 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature