Repeated mild traumatic brain injury causes focal response in lateral septum and hippocampus.

ABSTRACT:

Aim

To advance our understanding of regional and temporal cellular responses to repeated mild traumatic brain injury (rmTBI), we used a mouse model of rmTBI that incorporated acceleration, deceleration and rotational forces.

Materials & methods

A modified weight-drop method was used to compare two inter-injury intervals, rmTBI-short (five hits delivered over 3 days) and rmTBI-long (five hits delivered over 15 days). Regional investigations of forebrain and midbrain histological alterations were performed at three post-injury time points (immediate, 2 weeks and 6 weeks).

Results

The rmTBI-short protocol generated an immediate, localized microglial and astroglial response in the dorsolateral septum and hippocampus, with the astroglial response persisting in the dorsolat

SUBMITTER: Acabchuk R 

PROVIDER: S-EPMC5222510 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature