Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice.

ABSTRACT:

Objective

Hyaluronan (HA) is a polymeric glucosaminoglycan that forms a provisional extracellular matrix in diseased vessels. HA is synthesized by 3 different HA synthases (HAS1, HAS2, and HAS3). Aim of this study was to unravel the role of the HAS3 isoenzyme during experimental neointimal hyperplasia.

Approach and results

Neointimal hyperplasia was induced in Has3-deficient mice by ligation of the carotid artery. HA in the media of Has3-deficient mice was decreased 28 days after ligation, and neointimal hyperplasia was strongly inhibited. However, medial and luminal areas were unaffected. Cell density, proliferation, and apoptosis were not altered, suggesting a proportional decrease of both, the number of cells and extracellular matrix. In addition, endothelial function as

SUBMITTER: Kiene LS 

PROVIDER: S-EPMC5222548 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature