Systematic engineering of uniform, highly efficient, targeted and shielded viral-mimetic nanoparticles.

ABSTRACT: In the past decades, numerous types of nanomedicines have been developed for the efficient and safe delivery of nucleic acid-based drugs for cancer therapy. Given that the destination sites for nucleic acid-based drugs are inside cancer cells, delivery systems need to be both targeted and shielded in order to overcome the extracellular and intracellular barriers. One of the major obstacles that has hindered the translation of nanotechnology-based gene-delivery systems into the clinic has been the complexity of the design and assembly processes, resulting in non-uniform nanocarriers with unpredictable surface properties and efficiencies. Consequently, no product has reached the clinic yet. In order to address this shortcoming, a multifunctional targeted biopolymer is genetically engineered

SUBMITTER: Karjoo Z 

PROVIDER: S-EPMC5222681 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature