Ozone and hypertensive disorders of pregnancy in Florida: Identifying critical windows of exposure.

ABSTRACT:

Introduction

Ozone (O₃) has been linked to hypertensive disorders of pregnancy (HDP). However, inconsistent results have been reported, and no study has examined the critical exposure windows during pregnancy.

Materials and methods

We used Florida birth vital statistics records to investigate the association between HDP and O₃ exposure among 655,529 pregnancies with conception dates between 2005 and 2007. Individual O₃ exposure was assessed at mothers' home address at the time of delivery using the Hierarchical Bayesian space-time statistical model. We examined the association during three predefined exposure windows including trimester 1, trimester 2, and trimesters 1&2, as well as in each week of the first two trimesters using distributed l

SUBMITTER: Hu H 

PROVIDER: S-EPMC5222744 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature