IL-4 impairs wound healing potential in the skin by repressing fibronectin expression.

ABSTRACT:

Background

Atopic dermatitis (AD) is characterized by intense pruritis and is a common childhood inflammatory disease. Many factors are known to affect AD development, including the pleiotropic cytokine IL-4. Yet little is known regarding the direct effects of IL-4 on keratinocyte function.

Objective and methods

In this report RNA sequencing and functional assays were used to define the effect of the allergic environment on primary keratinocyte function and wound repair in mice.

Results

Acute or chronic stimulation by IL-4 modified expression of more than 1000 genes expressed in human keratinocytes that are involved in a broad spectrum of nonoverlapping functions. Among the IL-4-induced changes, repression of fibronectin critically impaired the human keratinocyte woun

SUBMITTER: Serezani APM 

PROVIDER: S-EPMC5222746 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature