Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective.

ABSTRACT:

Background

Oral immunotherapy (OIT) is an effective experimental food allergy treatment that is limited by treatment withdrawal and the frequent reversibility of desensitization if interrupted. Newly diagnosed preschool children may have clinical and immunological characteristics more amenable to treatment.

Objective

We sought to test the safety, effectiveness, and feasibility of early OIT (E-OIT) in the treatment of peanut allergy.

Methods

We enrolled 40 children aged 9 to 36 months with suspected or known peanut allergy. Qualifying subjects reacted to peanut during an entry food challenge and were block-randomized 1:1 to receive E-OIT at goal maintenance doses of 300 or 3000 mg/d in a double-blinded fashion. The primary end point, sustained unresponsiveness at 4 wee

SUBMITTER: Vickery BP 

PROVIDER: S-EPMC5222765 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature