PANSAID - PAracetamol and NSAID in combination: study protocol for a randomised trial.

ABSTRACT:

Background

Effective postoperative pain management is essential for the rehabilitation of the surgical patient. No 'gold standard' exists after total hip arthroplasty (THA) and combinations of different nonopioid medications are used with virtually no evidence for additional analgesic efficacy compared to monotherapy. The objective of this trial is to investigate the analgesic effects and safety of paracetamol and ibuprofen alone and in combination in different dosages after THA.

Methods

PANSAID is a placebo-controlled, parallel four-group, multicentre trial with centralised computer-generated allocation sequence and allocation concealment and with varying block size and stratification by site. Blinding of assessor, investigator, caregivers, patients and statisticians. Patie

SUBMITTER: Thybo KH 

PROVIDER: S-EPMC5223299 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature