No convincing association between genetic markers and respiratory symptoms: results of a GWA study.

ABSTRACT:

Background

Respiratory symptoms are associated with accelerated lung function decline, and increased hospitalization and mortality rates in the general population. Although several environmental risk factors for respiratory symptoms are known, knowledge on genetic risk factors is lacking. We aim to identify genetic variants associated with respiratory symptoms by genome-wide association (GWA) analyses.

Methods

We conducted the first GWA study on cough, dyspnea and phlegm among 7,976 participants in the LifeLines I cohort and used the LifeLines II cohort (n = 5,260) and the Vlagtwedde-Vlaardingen cohort (n = 1,529) for replication.

Results

We identified 50 SNPs that were assessed for replication. Rs16918212, located in the alpha-2-macroglobulin pseudogene 1 (A2MP1), wa

SUBMITTER: Zeng X 

PROVIDER: S-EPMC5223330 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature