MS_HistoneDB, a manually curated resource for proteomic analysis of human and mouse histones.

ABSTRACT:

Background

Histones and histone variants are essential components of the nuclear chromatin. While mass spectrometry has opened a large window to their characterization and functional studies, their identification from proteomic data remains challenging. Indeed, the current interpretation of mass spectrometry data relies on public databases which are either not exhaustive (Swiss-Prot) or contain many redundant entries (UniProtKB or NCBI). Currently, no protein database is ideally suited for the analysis of histones and the complex array of mammalian histone variants.

Results

We propose two proteomics-oriented manually curated databases for mouse and human histone variants. We manually curated >1700 gene, transcript and protein entries to produce a non-redundant list of 83 mou

SUBMITTER: El Kennani S 

PROVIDER: S-EPMC5223428 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature