The Effects of Migration and Assortative Mating on Admixture Linkage Disequilibrium.

ABSTRACT: Statistical models in medical and population genetics typically assume that individuals assort randomly in a population. While this simplifies model complexity, it contradicts an increasing body of evidence of nonrandom mating in human populations. Specifically, it has been shown that assortative mating is significantly affected by genomic ancestry. In this work, we examine the effects of ancestry-assortative mating on the linkage disequilibrium between local ancestry tracks of individuals in an admixed population. To accomplish this, we develop an extension to the Wright-Fisher model that allows for ancestry-based assortative mating. We show that ancestry-assortment perturbs the distribution of local ancestry linkage disequilibrium (LAD) and the variance of ancestry in a population as a f

SUBMITTER: Zaitlen N 

PROVIDER: S-EPMC5223515 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature