COME: a robust coding potential calculation tool for lncRNA identification and characterization based on multiple features.

ABSTRACT: Recent genomic studies suggest that novel long non-coding RNAs (lncRNAs) are specifically expressed and far outnumber annotated lncRNA sequences. To identify and characterize novel lncRNAs in RNA sequencing data from new samples, we have developed COME, a coding potential calculation tool based on multiple features. It integrates multiple sequence-derived and experiment-based features using a decompose-compose method, which makes it more accurate and robust than other well-known tools. We also showed that COME was able to substantially improve the consistency of predication results from other coding potential calculators. Moreover, COME annotates and characterizes each predicted lncRNA transcript with multiple lines of supporting evidence, which are not provided by other tools. Remarkably,

SUBMITTER: Hu L 

PROVIDER: S-EPMC5224497 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature