Hyperbilirubinemia Influences Sleep-Wake Cycles of Term Newborns in a Non-Linear Manner.

ABSTRACT: Hyperbilirubinemia is a common cause for irreversible neuronal influence in the brain of term newborns, while the feature of neurological symptoms associated with hyperbilirubinemia has not been well characterized yet. In the present study, we examined a total of 203 neonates suffering from hyperbilirubinemia with a bedside amplitude-integrated Electroencephalography (aEEG) device, in order to determine whether there is any special change in sleep-wake cycles (SWCs). Among these patients, 14 cases showed no recognizable SWCs with the total serum bilirubin (TSB) level at 483.9-996.2 μmol/L; 75 cases exhibited reduced SWCs with the TSB level at 311.2-688.5 μmol/L; and the rest cases had the normal SWCs. The number of the normal SWCs occurrence had a significant negative correlation with the

SUBMITTER: Zhang L 

PROVIDER: S-EPMC5224785 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature