LncRNA PVT1 regulates prostate cancer cell growth by inducing the methylation of miR-146a.

ABSTRACT: Prostate cancer is the third most common causes of death from cancer in men. Our previous study demonstrated that lncRNA PVT1 was overexpressed and played an oncogenic role in the progression of prostate cancer. However, the molecular mechanism of modulating the prostate cancer tumorigenesis was still unknown. In this study, we aim to investigate the interaction between PVT1 and miR-146a in prostate cancer and reveal the potential mechanism in prostate cancer carcinogenesis. The expression level of miR-146a was assessed by quantitative RT-PCR. The correlation analysis and methylation status analysis was made to confirm the interaction between PVT1 and miR-146a. Biological function analysis was performed through gain-of-function and loss-of-function strategies. Our results showed that miR-1

SUBMITTER: Liu HT 

PROVIDER: S-EPMC5224852 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature