Volume Delivered During Recruitment Maneuver Predicts Lung Stress in Acute Respiratory Distress Syndrome.

ABSTRACT:

Objective

Global lung stress varies considerably with low tidal volume ventilation for acute respiratory distress syndrome. High stress despite low tidal volumes may worsen lung injury and increase risk of death. No widely available parameter exists to assess global lung stress. We aimed to determine whether the volume delivered during a recruitment maneuver (V(RM)) is inversely associated with lung stress and mortality in acute respiratory distress syndrome.

Design

Substudy of an acute respiratory distress syndrome clinical trial on esophageal pressure-guided positive end-expiratory pressure titration.

Setting

U.S. academic medical center.

Patients

Forty-two patients with acute respiratory distress syndrome in whom airflow, airway pressure, and esophageal pres

SUBMITTER: Beitler JR 

PROVIDER: S-EPMC5224862 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature