Association Study with 77 SNPs Confirms the Robust Role for the rs10830963/G of MTNR1B Variant and Identifies Two Novel Associations in Gestational Diabetes Mellitus Development.

ABSTRACT:

Context

Genetic variation in human maternal DNA contributes to the susceptibility for development of gestational diabetes mellitus (GDM).

Objective

We assessed 77 maternal single nucleotide gene polymorphisms (SNPs) for associations with GDM or plasma glucose levels at OGTT in pregnancy.

Methods

960 pregnant women (after dropouts 820: case/control: m99'WHO: 303/517, IADPSG: 287/533) were enrolled in two countries into this case-control study. After genomic DNA isolation the 820 samples were collected in a GDM biobank and assessed using KASP (LGC Genomics) genotyping assay. Logistic regression risk models were used to calculate ORs according to IADPSG/m'99WHO criteria based on standard OGTT values.

Results

The most important risk alleles associated with GDM were

SUBMITTER: Rosta K 

PROVIDER: S-EPMC5224877 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature