Reading the Evolution of Compartmentalization in the Ribosome Assembly Toolbox: The YRG Protein Family.

ABSTRACT: Reconstructing the transition from a single compartment bacterium to a highly compartmentalized eukaryotic cell is one of the most studied problems of evolutionary cell biology. However, timing and details of the establishment of compartmentalization are unclear and difficult to assess. Here, we propose the use of molecular markers specific to cellular compartments to set up a framework to advance the understanding of this complex intracellular process. Specifically, we use a protein family related to ribosome biogenesis, YRG (YlqF related GTPases), whose evolution is linked to the establishment of cellular compartments, leveraging the current genomic data. We analyzed orthologous proteins of the YRG family in a set of 171 proteomes for a total of 370 proteins. We identified ten YRG protei

SUBMITTER: Mier P 

PROVIDER: S-EPMC5224878 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature