Inhibition of hepatitis C virus using siRNA targeted to the virus and Hsp90.

ABSTRACT: Hepatitis C (HCV) is a viral disease affecting millions of people worldwide, and persistent HCV infection can lead to progressive liver disease with the development of liver cirrhosis and hepatocellular carcinoma. During treatment for hepatitis C, the occurrence of viral resistance is common. To reduce the occurrence of resistance, new viral treatments should target both viral and cellular factors. Many interactions occur between viral and host proteins during the HCV replication cycle and might be used for the development of new therapies against hepatitis C. Heat shock protein 90 (Hsp90) plays a role in the folding of cellular and viral proteins and also interacts with HCV proteins. In the present study, we knocked down the expression of the Hsp90 gene and inhibited viral replication usi

SUBMITTER: Braga AC 

PROVIDER: S-EPMC5225065 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature