Increased functional connectivity between the default mode and salience networks in unmedicated adults with obsessive-compulsive disorder.

ABSTRACT: Deficits in attention have been implicated in Obsessive-Compulsive Disorder (OCD), yet their neurobiological bases are poorly understood. In unmedicated adults with OCD (n = 30) and healthy controls (n = 32), they used resting state functional connectivity MRI (rs-fcMRI) to examine functional connectivity between two neural networks associated with attentional processes: the default mode network (DMN) and the salience network (SN). They then used path analyses to examine putative relationships across three variables of interest: DMN-SN connectivity, attention, and OCD symptoms. In the OCD compared with healthy control participants, there was significantly reduced inverse connectivity between the anterior medial prefrontal cortex (amPFC) and the anterior insular cortex, regions within the D

SUBMITTER: Posner J 

PROVIDER: S-EPMC5225141 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature