Etirinotecan pegol administration is associated with lower incidences of neutropenia compared to irinotecan administration.

ABSTRACT:

Purpose

The relationship between incidences of neutropenia and 10-hydroxy-7-ethyl camptothecin (SN38) exposure was explored using SN38 pharmacokinetic and neutrophil count data from toxicology studies of etirinotecan pegol (EP) and irinotecan in beagle dogs.

Methods

Dogs received four weekly intravenous infusions of either vehicle control (n = 22), EP (6, 15, 20, 25, 40/25 mg/kg; n = 3-9 dogs/dose group/sex; n = 48), or irinotecan (20 or 25 mg/kg n = 3-4 dogs/dose group/sex; n = 14). Blood samples were collected up to 50 days post-dose for characterization of SN38 pharmacokinetics. Two separate models were created describing SN38 concentration time profiles after either irinotecan or EP administrations to project the AUC_0-168h after Day 1 and Day 22 doses. The rel

SUBMITTER: Sy SK 

PROVIDER: S-EPMC5225190 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature