Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II.

ABSTRACT: The mycotoxins altertoxin I and II (ATX I and II) are secondary metabolites produced by Alternaria alternata fungi and may occur as food and feed contaminants, especially after long storage periods. Although the toxic potential of altertoxins has been previously investigated, little is known about the pathways that play a role in their intracellular metabolism. In order to identify potential targets of ATX I and ATX II, the two toxins were tested for interaction with the nuclear factor erythroid-derived 2-like 2/antioxidant response element (Nrf2/ARE) pathway in mammalian cells. This pathway can be activated by various stressors resulting in the expression of enzymes important for metabolism and detoxification. In the present study, only ATX II triggered a concentration-dependent increase

SUBMITTER: Jarolim K 

PROVIDER: S-EPMC5225202 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature