Brain glutamate in anorexia nervosa: a magnetic resonance spectroscopy case control study at 7 Tesla.

ABSTRACT:

Rationale

Anorexia nervosa (AN) is a serious psychiatric disorder with high morbidity and mortality. There are no established pharmacological treatments and the neurobiology of the condition is poorly understood. Previous studies using magnetic resonance spectroscopy (MRS) have shown that AN may be associated with reductions in indices of brain glutamate; however, at conventional field strengths (≤3 T), it is difficult to separate glutamate from its precursor and metabolite, glutamine.

Objectives

The objective of the present study was to use high field (7 T) MRS to measure concentrations of glutamate, in three separate brain voxels, in women with AN.

Methods

We studied 13 female participants with AN and 12 healthy female controls who underwent MRS scanning at 7 T with

SUBMITTER: Godlewska BR 

PROVIDER: S-EPMC5225214 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature