Monocyte Activation Is Associated With Worse Cognitive Performance in HIV-Infected Women With Virologic Suppression.

ABSTRACT:

Background

 Cognitive impairment persists despite suppression of plasma human immunodeficiency virus (HIV) RNA. Monocyte-related immune activation is a likely mechanism. We examined immune activation and cognition in a cohort of HIV-infected and uninfected women from the Women's Interagency HIV Study (WIHS).

Methods

 Blood levels of activation markers, soluble CD163 (sCD163), soluble CD14 (sCD14), CRP, IL-6, and a gut microbial translocation marker (intestinal fatty acid binding protein (I-FABP)) were measured in 253 women (73% HIV-infected). Markers were compared to concurrent (within ± one semiannual visit) neuropsychological testing performance.

Results

 Higher sCD163 levels were associated with worse overall performance and worse verbal learning, verbal memory, ex

SUBMITTER: Imp BM 

PROVIDER: S-EPMC5225255 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature