Herb pair Danggui-Honghua: mechanisms underlying blood stasis syndrome by system pharmacology approach.

ABSTRACT: Herb pair Danggui-Honghua has been frequently used for treatment of blood stasis syndrome (BSS) in China, one of the most common clinical pathological syndromes in traditional Chinese medicine (TCM). However, its therapeutic mechanism has not been clearly elucidated. In the present study, a feasible system pharmacology model based on chemical, pharmacokinetic and pharmacological data was developed via network construction approach to clarify the mechanisms of this herb pair. Thirty-one active ingredients of Danggui-Honghua possessing favorable pharmacokinetic profiles and biological activities were selected, interacting with 42 BSS-related targets to provide potential synergistic therapeutic actions. Systematic analysis of the constructed networks revealed that these targets such as HMOX1,

SUBMITTER: Yue SJ 

PROVIDER: S-EPMC5225497 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature