Enhanced candicidal compound production by a new soil isolate Penicillium verruculosum MKH7 under submerged fermentation.

ABSTRACT:

Background

Microorganisms are a rich source of structurally diverse secondary metabolites that exert a major impact on the control of infectious diseases and other medical conditions. The biosynthesis of these metabolites can be improved by manipulating the nutritional or environmental factors. This work evaluates the effects of fermentation parameters on the production of a lactone compound effective against Candida albicans by Penicillium verruculosum MKH7 under submerged fermentation. Design-Expert version8.0 software was used for construction of the experimental design and statistical analysis of the experimental data.

Results

The important factors influencing antibiotic production selected in accordance with the Plackett-Burman design were found to be initial pH, temper

SUBMITTER: Talukdar S 

PROVIDER: S-EPMC5225592 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature