PET imaging of tenascin-C with a radiolabeled single-stranded DNA aptamer.

ABSTRACT:

Unlabelled

Tenascin-C is an extracellular matrix glycoprotein that is expressed by injured tissues and by various cancers. Recent publications showed that tenascin-C expression by cancer lesions predicts tumor growth, metastasis, and angiogenesis, suggesting tenascin-C as a potential therapeutic target. Currently there is no noninvasive method to determine tumoral tenascin-C expression in vivo. To address the need for an agent to image and quantify tenascin-C, we report the development of a radioactive PET tracer based on a tenascin-C-specific single-stranded DNA aptamer (tenascin-C aptamer).

Methods

Tenascin-C aptamer was radiolabeled with (18)F and (64)Cu. PET imaging studies for the evaluation of tumor uptake and pharmacokinetics of tenascin-C aptamer were performed in co

SUBMITTER: Jacobson O 

PROVIDER: S-EPMC5226408 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature