Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case-Control Study in Spain and Italy.

ABSTRACT:

Background

Evidence on the association between colorectal cancer and exposure to disinfection by-products in drinking water is inconsistent.

Objectives

We assessed long-term exposure to trihalomethanes (THMs), the most prevalent group of chlorination by-products, to evaluate the association with colorectal cancer.

Methods

A multicenter case-control study was conducted in Spain and Italy in 2008-2013. Hospital-based incident cases and population-based (Spain) and hospital-based (Italy) controls were interviewed to ascertain residential histories, type of water consumed in each residence, frequency and duration of showering/bathing, and major recognized risk factors for colorectal cancer. We estimated adjusted odds ratios (OR) for colorectal cancer in association with q

SUBMITTER: Villanueva CM 

PROVIDER: S-EPMC5226692 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature