Genome-wide survey in African Americans demonstrates potential epistasis of fitness in the human genome.

ABSTRACT: The role played by epistasis between alleles at unlinked loci in shaping population fitness has been debated for many years and the existing evidence has been mainly accumulated from model organisms. In model organisms, fitness epistasis can be systematically inferred by detecting nonindependence of genotypic values between loci in a population and confirmed through examining the number of offspring produced in two-locus genotype groups. No systematic study has been conducted to detect epistasis of fitness in humans owing to experimental constraints. In this study, we developed a novel method to detect fitness epistasis by testing the correlation between local ancestries on different chromosomes in an admixed population. We inferred local ancestry across the genome in 16,252 unrelated Afri

SUBMITTER: Wang H 

PROVIDER: S-EPMC5226866 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature