Calorie Restriction Attenuates Terminal Differentiation of Immune Cells.

ABSTRACT: Immune senescence is a natural consequence of aging and may contribute to frailty and loss of homeostasis in later life. Calorie restriction increases healthy life-span in C57BL/6J (but not DBA/2J) mice, but whether this is related to preservation of immune function, and how it interacts with aging, is unclear. We compared phenotypic and functional characteristics of natural killer (NK) cells and T cells, across the lifespan, of calorie-restricted (CR) and control C57BL/6 and DBA/2 mice. Calorie restriction preserves a naïve T cell phenotype and an immature NK cell phenotype as mice age. The splenic T cell populations of CR mice had higher proportions of CD11a^-CD44^lo cells, lower expression of TRAIL, KLRG1, and CXCR3, and higher expression of CD127, compared to contro

SUBMITTER: White MJ 

PROVIDER: S-EPMC5226962 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature