Identification of candidate genes in osteoporosis by integrated microarray analysis.

ABSTRACT:

Objectives

In order to screen the altered gene expression profile in peripheral blood mononuclear cells of patients with osteoporosis, we performed an integrated analysis of the online microarray studies of osteoporosis.

Methods

We searched the Gene Expression Omnibus (GEO) database for microarray studies of peripheral blood mononuclear cells in patients with osteoporosis. Subsequently, we integrated gene expression data sets from multiple microarray studies to obtain differentially expressed genes (DEGs) between patients with osteoporosis and normal controls. Gene function analysis was performed to uncover the functions of identified DEGs.

Results

A total of three microarray studies were selected for integrated analysis. In all, 1125 genes were found to be significant

SUBMITTER: Li JJ 

PROVIDER: S-EPMC5227060 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature