Fibred confocal fluorescence microscopy in the diagnosis of interstitial lung diseases.

ABSTRACT:

Background

Accurate diagnosis is critical to both therapeutic decisions and prognostication in interstitial lung diseases (ILD). However, surgical lung biopsies carry high complication rates. Fibred confocal fluorescence microscopy (FCFM) offers an alternative as it can visualize lung tissue in vivo at the cellular level with minimal adverse events. We wanted to investigate the diagnostic utility, and safety of using FCFM for patients with ILD.

Methods

In patients with suspected ILD, FCFM images were obtained from multiple bronchopulmonary segments using a miniprobe inserted through the working channel of a flexible bronchoscope. The procedure was performed under moderate sedation in an outpatient setting. Morphometric measurements and fibre pattern analyses were co-r

SUBMITTER: Meng P 

PROVIDER: S-EPMC5227198 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature