Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues.

ABSTRACT: Histone-modifying enzymes regulate transcription and are sensitive to availability of endogenous small-molecule metabolites, allowing chromatin to respond to changes in environment. The gut microbiota produces a myriad of metabolites that affect host physiology and susceptibility to disease; however, the underlying molecular events remain largely unknown. Here we demonstrate that microbial colonization regulates global histone acetylation and methylation in multiple host tissues in a diet-dependent manner: consumption of a "Western-type" diet prevents many of the microbiota-dependent chromatin changes that occur in a polysaccharide-rich diet. Finally, we demonstrate that supplementation of germ-free mice with short-chain fatty acids, major products of gut bacterial fermentation, is suffici

SUBMITTER: Krautkramer KA 

PROVIDER: S-EPMC5227652 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature